Seminar Mauro Silva

Dr. Mauro Silva
University of Otago, Centre for Neuroendocrinology, New Zealand
Time/Location: 06.09.2018 at 4:00 pm
New Biology Building / D4._2.303
invited by:
Prof. Dr. Inga Neumann
Dissecting the ontogeny and functional relevance of altered GABAergic circuitry in polycystic ovary syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is the most common cause of female infertility worldwide, yet this prevalent endocrine disorder remains poorly understood. Although classically considered an ovarian disease leading to hyperandrogenism, altered brain wiring and neuroendocrine derangements may play a central role in the development of PCOS. In particular, enhanced GABAergic innervation on gonadotropin-releasing hormone (GnRH) neurons is present in a prenatally androgenized (PNA) mouse model of PCOS. This enhanced GABAergic contact is primarily originated from the arcuate nucleus (ARN GABA) of the hypothalamus, a brain region which regulates fertility and metabolism, and may be involved in the pathophysiology of the disorder. However, the ontogeny of these GABAergic abnormalities and the specific biological relevance of ARN GABA neurons remained unknown. This talk will address these two main topics, which were part of my PhD studies under the supervision of Dr Rebecca Campbell (University of Otago, Centre for Neuroendocrinology – New Zealand). Firstly, I will walk you through the main findings of this study from the discover of early GABAergic brain abnormalities to circuit plastic changes with possible therapeutic applications using our preclinical mouse model of the disease. Secondly, a focus on the application of in vivo optogenetics to investigate the role of specific GABAergic circuits controlling GnRH neurons in normal and PCOS-like condition will be presented. On a final note, we will discuss the contributions and limitations of the study in the attempt to decipher the importance of altered brain circuits in PCOS.
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When and where




16:15 h - 17:00 h


Universität Regensburg


New Biology Building / D4._2.303


Neuroscience Graduate Programme "Neurobiology of Emotion Dysfunctions"
(GRK 2174)


Fakult├Ąt Biologie und Vkl. Medizin
University of Regensburg
Universit├Ątsstr. 31
93053 Regensburg
Phone: +49 (0)941-943-3055




© 2018 GRK 2174

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